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Cross, J

The FDA label includes a boxed warning regarding thyroid C-cell tumors observed in rodent studies, contraindicating use in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

In the central nervous system, the main synthesis pathway of DA is from L-tyrosine, which is transformed into L-dopa by tyrosine hydroxylase (TH) and then decarboxylated by aromatic acid decarboxylase (AADC) in the iron and H4-biopterin dependent pathway to produce DA

This is accomplished, in large part, through the activation of the HIF-1 pathway which is considered to be a modulator in the transactivation of genes implicated in the altered metabolism observed in cancer cells