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The study found that while both methods were safe, topical administration was more effective at reducing inflammation (inhibition of inflammatory factors such as IL-6, TNF-, and Interferon-gamma) and improving tear stability (Heydari et al., 2023)

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Linearity plot for D-Carnitine

3.1 Short chain fatty acids The SCFAs are carboxylic acids with less than six carbons, produced by the fermentation of dietary fibers and non-digestible carbohydrates, that evade digestion by host enzymes in the upper gut and are metabolized by bacteria in the cecum and colon, with decline concentrations from proximal to the distal colon as the substrates used for fermentation are exhausted gradually (63)