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In the SURMOUNT-5 head-to-head trial in 2025, tirzepatide showed about 20.2% and semaglutide about 13.7% in the same study, which is the most direct comparison available

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Other concerns flagged included suspicions around the timeline between attaining ethical approval and actually commencing the study, the fact that the trial was not randomized considered by many to be the gold standard for clinical trials and the removal of four treated patients from the final dataset, three of whom were escalated to intensive care and one of whom died