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This varies a lot

Global, Regional, and National Burden of Diabetes from 1990 to 2021, with Projections of Prevalence to 2050: A Systematic Analysis for the Global Burden of Disease Study 2021

The biggest safety risk comes from using unregulated "research chemical" products rather than pharmaceutical-grade compounds from licensed pharmacies

One strategy is to apply mineral lotion or fluid before leaving the house and reserve sprays for quick touch-ups at the pool or beach
