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Description
To validate the functional importance of the secondary IGF1-binding site, we introduced Y487A and R488A mutations into IGF1R, and tested their effects on IGF1R activation
Jain N, O'Brien S, Thomas DA, Jabbour E, Faderl S, Ravandi F, Borthakur G , York S, Garris R, Cortes JE, Kantarjian HM

A.Abd-AllahE

First, they engineered different hIPSC lines with patient-derived germline NF1 mutations and with KIAA1549-BRAF fusion, then they differentiated these hIPSCs to multipotent human neural stem cells capable of generating both neuronal and glial lineage cells (hINPCs)
