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Arterioscler Thromb Vasc Biol 26(12):26142621 Andersson DC et al (2011) Mitochondrial production of reactive oxygen species contributes to the beta-adrenergic stimulation of mouse cardiomycytes

Because the ADC strands are design to preferentially hybridize with cellular miRNAs, the encapsulated siRNAs are released from core/shell nanoparticles into the nucleoplasm owing to strand displacement reactions (step V) and enter the RNAi pathway, knocking-down the expression of tumor-promoting genes

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