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Depletion of adenosine has been shown to reduce fibrosis, inflammation, and vasculopathy in two preclinical mouse models of SSc 61

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77 It also may lead to neurological complications in newborns, such as hypotonia, failure to thrive, central apnoeas, and seizures

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Another consideration is that not everyone can use semaglutide, whether FDA-approved or compounded

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They support fat metabolism, liver function, and energy production

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