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and A.S.: writingoriginal draft preparation, review and editing

The data on rhIGF-1 support the mechanistic rationale that an IGF-1 analog like LR3 (which has extended half-life and greater receptor availability in research settings) could enhance protein synthesis, stimulate cellular proliferation pathways and promote more efficient nutrient partitioning, though direct clinical trials of IGF-1 LR3 itself in humans are lacking

However, there are also cases when additional factors such as lack of sleep, poor diet, and deficiency of other vitamins like iron, folate, and others, contribute to the issue

2006 Dec;291(6):E1290-4