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Thus, the focus of KOA management remains on alleviating inflammatory conditions [35]


However, the tissues have a limited storage capacity for creatine and hence, high circulating creatine levels induce a negative feedback mechanism that inhibits the formation of GAA (Khajali et al., 2020)

[DOI] [PMC free article] [PubMed] [Google Scholar] 116.Gapp J, Tariq A, Chandra S
