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doi: 10.1016/j.chest.2018.10.042 12

Specific diagnostic tests for excipients should be performed when appropriate, including skin, in vitro and provocation testing with pure excipients and drugs with and without the excipient as controls

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As an important part of metabolic reprogramming in the tumors, reprogramming of glutamine metabolism is considered to have pleiotropic effects on cellular functions, such as macromolecule synthesis, energy generation, mTOR activation, maintenance of reactive oxygen species (ROS) balance and anti-tumor acidic microenvironment