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Description
Emanuelli M
25 Besides the aforementioned NNMT inhibitors through a ligand-based discovery, high throughput screening has led to the identification of JBSNF-000088 ( 4 ) that inhibited hNNMT, monkey NNMT, and mouse NNMT enzymatic activities with IC 50 values of 1.8, 2.8, and 5.0 M, respectively
Activity was monitored via quantification of radiolabeled reaction product DNA 5-[methyl- 3 H]-cytosine
[DOI] [PubMed] [Google Scholar] Loring H
