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This process can be reversed by the overexpression of PGC-1, which in turn restores mitochondrial biogenesis (Siddiqui et al., 2016

There were rapidly produced heart dilatation and lesions worsening (i.e., 1 min 12 mmol/L), arrhythmias with an ultimate and a regularly inevitable lethal outcome within 30 min [67] were both prevented with BPC 157 given before KCl application, as well as cured with BPC 157 therapy given later, in the conditions of the advanced and established huge hyperkalemia-induced disturbances