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Overexpression of p53 protein detected by IHC is coupled with TP53 mutation [316, 336, 559], worse OS [316, 336, 560], risk of leukemia progression [559, 561] and chromosomal abnormalities [316, 336, 559]
Natural nootropics such as herbs, vitamins, minerals, and amino acids are generally legal and sold as dietary supplements, while synthetic nootropics can be prescription only, restricted, or in a legal gray area
Agents that inhibit the cystine uptake via the cystine/glutamate antiporter (system x c - ) (e.g., sulfasalazine) or directly deplete the GSH from plasma (e.g., cyst(e)inase) triggers ferroptosis and arrests tumorigenesis [224, 225]
doi: 10.1158/1078-0432.CCR-12-3327 308 LiuJHuXFengLLinYLiangSZhuZet al
