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Notably, inflammatory responses play a dual role in tumorigenesis: they can both promote malignant transformation and metastasis and exert an antitumour effect via pyroptosis induction [66]

To overcome ROS-induced damage, both the host and pathogen developed antioxidant systems to quench excess ROS (Barna et al., Botrytis cinerea , causing the gray mold disease of plants (Veloso and van Kan, 2018)

Secondly, the redox status of the cell affects many of the enzymes in one-carbon metabolism including MATI, MATIII, MS, BHMT, as well as CBS and GCS in the transsulfuration pathway, and therefore one cannot evaluate GSH metabolism without including the methionine and folate cycles