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B12 is required for converting food into usable cellular energy

The likelihood of experiencing a deficiency in these patients was significantly increased, with a 2.45-fold risk according to a meta-analysis conducted by Niafar et al

However, they do not represent the full spectrum of MDR pathogens

Given its essential role in the detoxification of lipid hydroperoxides, and its overexpression in most of myeloid malignancies, GPX4 inhibition has emerged as a promising therapeutic strategy to specifically trigger ferroptosis and eradicate myeloid leukemia cells
