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2009 May 15;24(7):979-83

Keshavarzian A, Holmes EW, Patel M, Iber F, Fields JZ, Pethkar S

Enzyme replacement therapy for hypophosphatasia has shown promising results in human clinical trials, reducing mortality in hypophosphatasia and improving chondromalacia, lung function and exercise milestones in these patients [44]
However, about 40% of patients developed motor fluctuations and dyskinesias after 4 to 6 years of treatment [1], demonstrating that further pharmacological research is needed in order to counterbalance side effects
