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Description
More evidence of NAD+'s significance in promoting mitochondrial and metabolic health may be seen in murine cells overexpressing the NADase CD38, which also had greater lactate levels, aberrant mitochondria, including missing or enlarged cristae, and lower oxygen consumption (7)

doi: 10.1016/bs.mie.2021.12.009

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The classic presentation of symptomatic B 12 deficiency occurs in Addison-Biermers disease, and is characterised by megaloblastic anaemia
