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The increase in visceral fat may explain the changes in cholesterol fractions, which positively correlate with BMI, lipid peroxidation, and oxidized low-density lipoprotein (LDL) [50]

Among small molecules, tanzisertib and AS602801 have already reached early clinical testing in psoriasis, showing acceptable safety with attention to hepatotoxicity [26, 27]

Ascioti AJ, Hofstetter WL, Miller MJ, Rice DC , Swisher SG, Vaporciyan AA, Roth JA, Putnam JB, Smythe WR, Feig BW, Mansfield PF, Pisters PW, Torres MT, Walsh GL

Selectivity is the defining mechanism feature
