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Human causation remains unproven, but the drug is contraindicated in people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2

Average weight by day 21 (125 3.5g) was 9.4% lower than the initial weight (138 4.6g)

Therefore, inhibiting URAT1 effectively opens the "floodgates" for uric acid excretion
