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This study found a marked expression of monocyte-chemoattractant protein (MCP)-1, macrophage-inflammatory protein (MIP)-1 , MIP-1 , interferon- -inducible protein (IP)-10, interleukin (IL)-8, and RANTES in varicose veins, suggesting that chemokines might play an important role in their pathophysiology by recruiting leucocytes to the vein wall and contributing to inflammation and edema

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