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They may damage important biomolecules, including lipids, proteins, and DNA (Lobo et al., 2010)

GSH levels, turnover rates and/or oxidation state can be compromised by inherited or aquired defects in the enzymes, transporters, signaling molecules, or transcription factors that are involved in its homeostasis, or from exposure to reactive chemicals or metabolic intermediates

The 60.3% recurrence rate after stopping suggests ongoing treatment is needed, but long-term safety data for this specific population does not exist

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