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While the critical role of lipid metabolism and peroxidation in ferroptosis is established, the specific lipid peroxide species, generation mechanisms, subcellular localization, and cellular response pathways triggered by lipid peroxidation in AD remain poorly understood

The histone methyltransferase inhibitor 5-deoxy-5-methylthioadenosine (MTA) reverses histone methylation and prevents chromatin remodeling, effectively abrogating the trained immunity phenotype induced by oxLDL

12/15-lipoxygenase inhibition reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice