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The S 1 PESs for each antimetabolite contain two energy minima, one being the metal-to-ligand charge transfer (MLCT) and another the ligand- eld (LF) state

It is not a controlled substance, but it is also not approved as a therapeutic, dietary supplement, or anything else that would allow legal human use

The exact frequency will depend on how your body responds to the treatment and the underlying cause of your deficiency
