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While rheumatoid factor , an autoantibody directed against the Fc portion of IgG, is also commonly measured and highly sensitive, it lacks specificity

Deficiencies in B vitamins or imbalances in SAH and SAM increase GSH breakdown by GGT, releasing hydrogen sulfide (H2S)

However, the small sample-size, the short treatment period, the absence of control groups, the lack of liver biopsy evaluation after treatment are just some of the limitations of these studies