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J., Vannucci S

Third, given their reliance on lipid metabolism, B1 and MZB cells are extremely susceptible to lipid peroxidation and subsequent ferroptosis secondary to ROS accumulation 142

Nelumbo nucifera (lotus leaf) can clear heat-dampness and ascend and invigorate yang-qi.Its bioactive component, nuciferine, is a tetracyclic aporphine alkaloid that can effectively reduce renal lipid accumulation by regulating AMPK-mediated expression of FAS and hormone-sensitive triglyceride lipase (HSL) and inhibit inflammation and oxidative stress through the AMPK-mediated Nrf-2/HO-1 and TLR4/MyD88/NF-B pathways [125]

Moreover, their effect on laden cells was investigated