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Description
Many oral treatments have been studied, but results so far have been mixed.[5] Some consider the use of non-surgical approaches to be "controversial".[6] Vitamin E supplementation has been studied for decades, and some success has been reported in older trials, but those successes have not been reliably repeated in larger, newer studies.[7] A combination of Vitamin E and colchicine has shown some promise in delaying progression of the condition.[8] Newer agents targeting the basic mechanisms of inflammation have not yet been studied in larger clinical trials

Lactate accumulation acidifies the microenvironment, exacerbating ion dyshomeostasis and attracting neutrophil extracellular traps, web-like DNA structures that entangle MMP-9, amplifying BBB leakage [156] (Fig
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Acyl CoA transforms into acetyl CoA through -oxidation
