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On the other hand, a combination of acetylsalicylic acid plus sunitinib showed higher anti-proliferative, anti-angiogenic, anti-invasive, and pro-apoptotic effects on human primary GBM-endothelial cells than either drug alone, by inhibiting the release of VEGF, VEGFR1/2, HRAS, PI3K, AKT, MEK, and ERK, as well as by down-regulating Bcl-2 and up-regulating Bax [338,340]

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