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Chen and others 127 investigated the thermodynamic mechanism of the interaction between the active components of rhubarb and Coptis chinensis, tannic acid and berberine, and found that their combination was a spontaneous process

Tryptophan increased also the circulating levels of melatonin, particularly in the portal circulation and these changes of melatonin levels in GIT following tryptophan application were unaffected by prior pinealectomy, but greatly reduced by a partial ligature of the portal vein (8)

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