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Ratios of classical monocytes (CD14-/CD16-), which are more responsible for phagocytosis and initiation/priming of the immune system [254], are higher in patients with ALS and pre-symptomatic SOD1 carriers as compared with healthy controls, but function at a decreased efficacy and invade the CNS, though the difference between the roles of monocytes in the CNS versus systemic circulation are still unknown [255]

Moreover, while antibiotic treatment can suppress plasma TMAO levels, such as with metronidazole and ciprofloxacin, continued use of antibiotics to lower TMAO concentrations can lead to resistance in bacterial strains

Crosstalk between glucose metabolism, lactate production and immune response modulation

Vitamins C and E, flavonoids, and carotenoids are also effective in reducing oxidative stress in diabetes