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Strategic Exercise (Quality Over Quantity) Exercise prescription in perimenopause needs to change: Strength training priority: 3-4x/week focusing on progressive overload to combat muscle loss Strategic cardio: Less chronic cardio, more HIIT for metabolic benefit without cortisol spike Recovery emphasis: Adequate rest between sessions

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The first screening step analyzed the ability of ~20,000 chemically diverse drug-like structures to prevent the aggregation of prion proteins (PrP), with 3,5-diphenyl-pyrazole (DPP) being the one with the highest activity level