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We report three major findings: (1) patients with FEP with higher GSH levels in ACC show a rapid symptom reduction upon starting antipsychotic treatment, (2) when compared with healthy controls, GSH levels in patients are dissociated from glutamate levels, and (3) Glutamate excess predicts the degree of Social and Occupational dysfunction seen at the time of presentation with FEP

doi: 10.1016/j.neuropharm.2016.03.013

Moreover, these changes in the solvent properties can greatly alter the degree of solvation of the solute, eventually affecting the partitioning of the molecule

Participants will be stratified based on the version of the BOSCC that they are allocated (i.e