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The main mutagenic lesion is 8oxoguanine (8oxodG), which can base pair with adenine rather than cytosine and lead to transversion mutations once DNA replication is completed [86]
The role of hydrogen sulfide in aging and age-related pathologies
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This, coupled with a lack of sensitive and specific diagnostic markers, and quantitative biomarkers of progression, has hampered clinical trials for disease modification in PD 3
