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Description
It modulates over 4,000 human genes, upregulating collagen (COL1A1) and elastin while downregulating pro-inflammatory cytokines like TGF-1 and IL-6

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In most cases, mitophagy is triggered upon oxidative stress and serves as a cellular defense mechanism to remove damaged mitochondria that produce high levels of ROS [96]

Patients with STAT5b mutations also have raised serum prolactin levels which can also be helpful with diagnosis
