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High dietary intake of ALA reduced sickle RBCs, liver fibrosis, and adhesion molecule expression, in multiple organs as well

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In the absence of myelin, redistribution of Na + occurs to maintain the transmission of nerve impulses that increases energy demand, and this produces a situation of virtual hypoxia. At the end, the demand exceeds the capacity of axonal mitochondria to produce enough ATP, which causes an increase in the concentration of Ca 2+ in the axon