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S2A and Fig

and (5) the dephosphorylation and inactivation of RR [45]

The yeast elicits these protective effects through mechanisms that reduce visceral hypersensitivity and modulate pro-inflammatory cytokine signaling, thereby establishing a microenvironment that promotes tissue recovery (314)

Other concerns flagged included suspicions around the timeline between attaining ethical approval and actually commencing the study, the fact that the trial was not randomized considered by many to be the gold standard for clinical trials and the removal of four treated patients from the final dataset, three of whom were escalated to intensive care and one of whom died