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4.4 Practical considerations in pharmacokinetics and administration routes The synovial cavity, as a natural enclosed space, provides an ideal window for local drug delivery, allowing drugs to act on the lesion site at high concentrations while minimizing systemic exposure and associated potential risks (Yu et al., 2024

Increased peroxidation of lipids in AD or preclinical AD brains or cerebrospinal fluids is proven by enhanced levels of protein-conjugated 4-hydroxy-2-nonenal (HNE), F 4 , and F 2 isoprostanes (Halliwell 2006)

Both of these vitamins have antioxidant properties ( Furthermore, those who received a chlorella supplement also showed a significant decrease in DNA damage ( In another study, 30 people with chronic obstructive pulmonary disease (COPD) consumed either 1 or 2 grams of spirulina daily for 60 days
