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10.1016/j.toxlet.2014.11.005
Importantly, AdoHcy is a critically endogenous inhibitor of cellular methyltransferases, HHcy is easy to form hypomethylating environment, which further impairs methylation reactions related to intimal homeostasis (105)
68 While defining an optimal microbiome composition is challenging due to individual variability and heterogeneity, focusing on metabolite profiles provides a more consistent and stable metric for understanding microbiome impacts
doi: 10.1164/rccm.201910-1911TR 12
