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They tested these inhibitors in cell and animal models. They reported changes in intracellular nicotinamide-related metabolites and examined the biological effects of NNMT inhibition under experimental conditions. These outcomes have increased scientific interest in NNMT biology

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Sirtuin control of mitochondrial dysfunction, oxidative stress, and inflammation in chagas disease models

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Nakamura, E

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Neuroinflammatory processes are a central feature in the development of degenerative disease

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