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Ursodeoxycholic acid (UDCA) has been found ineffective for pruritus relief in primary sclerosing cholangitis and primary biliary cholangitis but is recommended for treating pruritus in intrahepatic cholestasis of pregnancy only, at doses of 1015 mg/kg/day, divided into 23 doses

The average fluorescence intensity of KGN cells in each experimental group was recorded using the fluorescein isothiocyanate (FITC) channel of a NovoCyte 2040R flow cytometer (Beckman Coulter, Inc.) and analyzed using NovoExpress 1.1.0 (Agilent Technologies, Inc.) within 1 h