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doi: 10.1038/s41422-024-00929-0 40 NimgampalleMChakravarthyHSharmaSShreeSBhatARPradeepkiranJAet al

however, the technology exists in early form such as experiments in using the prepro-orexin transgene via gene editing restored normal function in mice models by making other neurons produce orexin after the original set have been destroyed, or replacing the missing orexinergic neurons with hypocretin stem cell transplantation, are both steps in that direction for fixing the biology effectively permanently once applied in humans

The Role of Mitochondrial Calcium Homeostasis in Alzheimers and Related Diseases