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Results For all dogs, rapamycin Tmax was 2 hours
The removal of superoxide radicals by SOD prevents the formation of the much more damaging peroxynitrite ONOO (O2 +NOONOO) and maintains the physiologically relevant level of nitric oxide (NO), an important molecule in neurotransmission, inflammation, and vasodilation

Ascorbate-derived imaging probes for hyperpolarized 13C magnetic resonance spectroscopy and positron emission tomography have been used to study redox changes (antioxidant depletion and reactive oxygen species accumulation) in vivo
