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Similarly, the severity of the damage caused during in vitro heat stress was related to the highest temperatures selected, where temperatures over 38.5 C caused major injuries to the oocyte quality parameters assessed and blastocyst rates

In fact, since the cells of the gut will see the highest doses of metformin they will experience the greatest level of inhibited complex I which may explain the gastrointestinal side effects (nausea, diarrhea, anorexia) of the drug that limit its utility in many patients