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At the molecular level, the activated progesterone receptor (PR) functions as a molecular rheostat for the oestrogen receptor (ER), modulating its chromatin binding and transcriptional activity 13
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MET does this by upregulating the expression of EMT markers such as vimentin and Snail and the expression or activity of matrix metalloproteinases (MMPs), which digest the surrounding stroma to promote invasion [78,79,80]
Research shows that curcumin effectively manages liver diseases by reducing inflammation, combating oxidative stress, and promoting liver cell regeneration
