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In addition, hypoxia/ischemia and hypothermia approaches are emerging strategies to improve patients prognosis [187, 188]

Laboratory studies suggest the peptide can shift gene-expression patterns toward a profile associated with younger tissue and may support the activity of cells involved in repair

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An even more challenging task will be to elucidate the functional impact of such changes, both in terms of their quantitative influence on the biological activity of the affected protein, as well as their fractional control over the integrated network of subcellular and cellular regulation