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doi: 10.1016/j.jacc.2017.09.028

While they can be startling, they are often harmless and triggered by stress, caffeine, or dehydration

In allergic airway models, TLR ligands of bacterial origin have been shown to have differential effects on various adaptive and innate immune cells, including B cells, and play a role in IgE secretion and allergic inflammation

Acute injury protocols typically run 4 to 6 weeks with a subsequent 2 to 4 week break before reassessment
