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Description
A 2018 review by Sikiric described its effects on the VEGF pathway, which drives the formation of new blood vessels (angiogenesis), and on the nitric oxide system, which regulates blood flow and inflammation

This framework helps distinguish whether an individual has actual nutrient insufficiency, mitochondrial stress, or metabolic dysfunction that might benefit from component-level support versus lifestyle intervention alone

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Key demonstrated actions include: Stimulates endogenous growth hormone (GH) secretion through GHRH receptor activation
