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Due to the existence of the conjugated system of C = C bonds and carbonyl groups, 4-HNE can provide partial positive charge to the carbon at position three and become efficient electrophiles, allowing it to react with essential biological molecules, including proteins and DNA (107109)
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[DOI] [PMC free article] [PubMed] [Google Scholar] Rajan 2002 Rajan S, Wallace JI, Beresford SA, Brodkin KI, Allen RA, Stabler SP
