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Until now, only a highly charged denaturant (i.e., guanidine hydrochloride) or a strong acidic pH can lead to pentamer dissociation, regardless of the presence of calcium, possibly due to their ability to disrupt the electrostatic interactions that mediate calcium binding to CRP [31]

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3rd: (TS = (ferroptosis)) AND TS = (gut microbiota)

Conditions that are an integral part of a disease process