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Here, we propose the misfolding of the mutant ATXN3 protein and the subsequent aggregation process, with eventual deposition of insoluble intracellular aggregates, to be the hub of the pathogenic process, and discuss how protein dyshomeostasis impacts key cellular pathways causing dysfunction and disease (Fig

Three weeks after the surgery, the PGA-collagen tube was observed to facilitate recovery from nerve degeneration among the heat stimulation-induced sensory threshold, MEPs, and via pathological observation of the myelinated nerve fiber

The cuprizone-containing pellets were formed using cuprizone powder from the same batch as that delivered directly to the mice, to minimise any batch or supplier variability

Probiotics such as Bifidobacterium longum can influence enteric glial cells, promoting the secretion of neurotrophic factors like GDNF, which support neuronal health and reduce inflammation