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Comprehensive validation of AI algorithms across diverse patient populations is necessary to avoid biased outcomes and to confirm reliability under varied clinical scenarios [246]

Their analyses reported that GHK's signature was associated with expression changes across a large number of human genes, including genes related to extracellular-matrix homeostasis, inflammation, and DNA repair, and they framed these associations as consistent with a broad, multi-gene profile rather than a single-pathway effect [4]

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